Gene ID: 855744, updated on 17-May-2024
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Summary
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- Gene symbol
- CSE2
- Gene description
- Cse2p
- Primary source
- FungiDB:YNR010W
- Locus tag
- YNR010W
- See related
- SGD:S000005293; AllianceGenome:SGD:S000005293; VEuPathDB:YNR010W
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
- Saccharomyces cerevisiae S288C (strain: S288C)
- Lineage
- Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
- Also known as
- MED9
- Summary
- Enables structural molecule activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context
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See CSE2 in Genome Data Viewer
- Location:
- chromosome: XIV
- Exon count:
- 1
- Sequence:
- Chromosome: XIV; NC_001146.8 (643744..644193)
Chromosome XIV - NC_001146.8![CSE2 Cse2p [Saccharomyces cerevisiae S288C] - Gene (1)](https://i0.wp.com/www.ncbi.nlm.nih.gov/gutils/geneneighb.fcgi?geneid=855744&nuc_gi=330443715&n0=LRO1&n1=NRM1&n2=CSE2&n3=PRP2&n4=URK1 "CSE2 Cse2p [Saccharomyces cerevisiae S288C] - Gene (1)")
Genomic regions, transcripts, and products
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Go to reference sequence details
- Genomic Sequence:
- NC_001146.8
Go to nucleotide: Graphics FASTA GenBank
Bibliography
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Related articles in PubMed
- Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. Xiao ZX, et al. J Mol Biol, 1995 Apr 28. PMID 7739039
- CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Xiao Z, et al. Mol Cell Biol, 1993 Aug. PMID 8336709, Free PMC Article
- SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Chen XH, et al. Mol Gen Genet, 1994 Aug 2. PMID 8058037
- Twelve open reading frames revealed in the 23.6 kb segment flanking the centromere on the Saccharomyces cerevisiae chromosome XIV right arm. Verhasselt P, et al. Yeast, 1994 Oct. PMID 7900425
- Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975
See all (101) citations in PubMed
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
- The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation and the carboxy-terminal half (aa 64-149) is involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9.
Title: Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation.
Submit: New GeneRIF Correction
Interactions
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| Products | Interactant | Other Gene | Complex | Source | Pubs | Description |
|---|
General gene information
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Gene Ontology Provided by SGD
| Function | Evidence Code | Pubs |
|---|---|---|
| enables structural molecule activity | IMP Inferred from Mutant Phenotype | PubMed |
| enables transcription coactivator activity | IDA Inferred from Direct Assay | PubMed |
| enables transcription coregulator activity | IEA Inferred from Electronic Annotation |
| Process | Evidence Code | Pubs |
|---|---|---|
| involved_in RNA polymerase II preinitiation complex assembly | IDA Inferred from Direct Assay | PubMed |
| involved_in negative regulation of transcription by RNA polymerase II | IMP Inferred from Mutant Phenotype | PubMed |
| involved_in positive regulation of transcription by RNA polymerase II | IMP Inferred from Mutant Phenotype | PubMed |
| involved_in regulation of transcription by RNA polymerase II | IEA Inferred from Electronic Annotation |
| Component | Evidence Code | Pubs |
|---|---|---|
| part_of core mediator complex | IDA Inferred from Direct Assay | PubMed |
| located_in cytosol | IDA Inferred from Direct Assay | PubMed |
| part_of mediator complex | IEA Inferred from Electronic Annotation | |
| located_in nucleus | IDA Inferred from Direct Assay | PubMed |
| located_in nucleus | IEA Inferred from Electronic Annotation |
General protein information
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- Preferred Names
- Cse2p
- NP_014407.3
-
- Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia
NCBI Reference Sequences (RefSeq)
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Genome Annotation
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference assembly
Genomic
-
NC_001146.8Reference assembly
- Range
- 643744..644193
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001183187.3 → NP_014407.3 TPA: Cse2p [Saccharomyces cerevisiae S288C]
See identical proteins and their annotated locations for NP_014407.3
Status: REVIEWED
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| Nucleotide | Protein | |
|---|---|---|
| Heading | Accession and Version | |
| Protein Accession | Links | |
|---|---|---|
| GenPept Link | UniProtKB Link | |
| 5OQM_j.1 | ||
| P33308.1 | ||
Additional links
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Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
- Dryad Digital Repository
- BioGRID Open Repository of CRISPR Screens (ORCS)
- Eukaryotic Promoter Database
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
- Addgene Non-profit plasmid repository
- GenScript latest version of gene cDNA ORF Clone
- OriGene
- InterologFinder.org
![CSE2 Cse2p [Saccharomyces cerevisiae S288C] - Gene (2024)](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR42mP8/h8AAvMB+NzmkbcAAAAASUVORK5CYII=)